Fig. 5.

Representative scattergraphs of tumour necrosis factor (TNF)-α⁺ and interleukin (IL)-5⁺ neutrophils employed to establish the concept of low cytokine producers (white), high proinflammatory (black) or anti-inflammatory/regulatory (grey) cytokine producers. Low cytokine-producers were defined for values of cytokine⁺ cells lower than the global median, whereas high cytokine producers were defined for values of cytokine⁺ cells higher or equal the global median cut-off.