Table 1.
Relationship of serum inflammatory mediators in the baboons at each time-point of the study
| Inflammatory analyte | Baseline | Mid-pregnancy | Delivery |
|---|---|---|---|
| CRP | LBP↓ | n.s. | MCP-1↑ |
| PGE2 | RANTES↑ | RANTES↑, BPI↑ | BPI↑, IL-6↓ |
| IL-6 | MCP-1↑ | n.s. | PGE2↓ |
| IL-8 | LBP↓ | MCP-1↑, BPI↓ | LBP↑, BPI↓ |
| MCP-1 | BPI↓, LBP↓ | n.s. | CRP↑ |
| RANTES | PGE2↑ | PGE2↑ | n.s. |
| BPI | MCP-1↓, LBP↑ | PGE2↑, LBP↑, IL-8↓ | PGE2↑, LBP↑, IL-8↓ |
| LBP | BPI↑, CRP↓, | BPI↑ | BPI↑, IL-8↑ |
| MCP-1↓, IL-8↓ |
The arrows (↓ negative; ↑ positive) denote the direction of relationship of the mediators. Only mediators with correlations with P < 0·001 are included. BPI, bactericidal permeability inducing factor; CRP, C-reactive protein; IL, interleukin; LBP, lipopolysaccharide binding protein; MCP, macrophage chemotactic protein; n.s., no significant relationship between any of the mediators; PGE2, prostaglandin E2; RANTES, regulated upon activation, normal T cell expressed and secreted.