Table 5.
Subgroup analyses of effects of vitamin D supplementation by pubertal status and compliance
| Outcome | Prepubertal and low compliance | Mixed pubertal and high compliance | ||||
|---|---|---|---|---|---|---|
| No of studies | No of participants | Standardised mean difference* (95% CI) | No of studies | No of participants | Standardised mean difference* (95% CI) | |
| Hip bone mineral density | 1 | 87 | −0.30 (−0.72 to 0.13) | 3 | 552 | 0.14 (−0.3 to 0.32) |
| Lumbar spine bone mineral density | 1 | 87 | −0.19 (−0.61 to 0.23) | 4 | 573 | 0.21 (0.04 to 0.38)†‡ |
| Total body bone mineral content | 1 | 87 | −0.22 (−0.64 to 0.20) | 4 | 585 | 0.15 (−0.02 to 0.32) |
| Forearm bone mineral density | 1 | 87 | 0.51 (0.08 to 0.93)† | 2 | 340 | −0.16 (−0.38 to 0.07) |
Outcome is percentage change from baseline.
*Standardised mean difference of 0.3 regarded as small.59
†Statistically significant at 5% level.
‡P=0.09 for difference.