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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Semin Hematol. 2011 Jan;48(1):13–21. doi: 10.1053/j.seminhematol.2010.11.004

Table 2.

International Myeloma Working Group Diagnostic Criteria [6]

MGUS M protein < 3.0 g/dL
AND
Clonal bone marrow plasma cells < 10%
AND
No evidence of end-organ damage (CRAB)
Smoldering Myeloma M protein > 3.0 g/dL
AND/OR
Clonal bone marrow plasma cells > 10%
AND
No evidence of end-organ damage (CRAB)
Multiple Myeloma M protein in serum or urine*
AND
Clonal bone marrow plasma cells or plasmacytoma
AND
Evidence of end-organ damage (CRAB)
   Hypercalcemia (Calcium > 11.5 g/dL)
   Renal Insufficiency (Creatinine > 2.0 mg/dL)
   Anemia (Hemoglobin < 10 g/dL or 2 g/dL below baseline)
   Bone disease (bone lytic lesions or osteoporosis)
*

Monoclonal protein may be absent in non-secretory multiple myeloma