Table 1.
Urinary 8-OHdG Concentration |
||||||||
Q1 (n =
251) |
Q2 (n =
251) |
Q3 (n =
252) |
Q4 (n =
251) |
|||||
% | Mean (SE) | % | Mean (SE) | % | Mean (SE) | % | Mean (SE) | |
Age, years | 57.2 (0.5) | 58.4 (0.5) | 59.2 (0.5) | 57.2 (0.5) | ||||
Female | 60.6 | 70.9 | 73.8 | 76.1** | ||||
Body mass index, kg/m2 | 32.5 (0.4) | 32.2 (0.4) | 31.7 (0.4) | 31.3 (0.4)* | ||||
Past smoker | 30.9 | 31.2 | 32.5 | 26.8 | ||||
Current smoker | 21.7 | 21.2 | 24.5 | 29.7* | ||||
Physical activity scoreb | 31.9 (0.3) | 31.5 (0.3) | 31.6 (0.3) | 30.9 (0.3)* | ||||
Past drinker | 31.1 | 28.0 | 34.7 | 37.6 | ||||
Current drinker | 41.8 | 44.4 | 35.1 | 38.4 | ||||
Presence of diabetes | 39.9 | 36.6 | 41.0 | 45.6 | ||||
Presence of hypertension | 71.8 | 68.0 | 73.8 | 68.2 | ||||
Plasma homocysteine, μmol/L | 8.6 (1.0) | 8.6 (1.0) | 8.5 (1.0) | 8.8 (1.0) | ||||
Presence of APOE*E2 | 15.7 | 12.6 | 18.0 | 9.6 | ||||
Presence of APOE*E4 | 0.75 | 4.2 | 1.6 | 2.3 | ||||
Poverty | 52.7 | 61.4 | 60.3 | 55.6 | ||||
CES-D score | 19.5 (0.8) | 20.0 (0.8) | 19.7 (0.8) | 21.1 (0.8) | ||||
Acculturation score | 24.2 (1.4) | 24.0 (1.3) | 23.0 (1.3) | 23.6 (1.3) |
Abbreviations: APOE*E2 and APOE*E4, alleles producing the ϵ2 and ϵ4 types of apolipoprotein E, respectively; CES-D, Center for Epidemiologic Studies Depression [Scale]; 8-OHdG, 8-hydroxy-2-deoxyguanosine; Q, quartile; SE, standard error.
* P < 0.05; **P < 0.01 relative to the lowest 8-OHdG quartile.
Means (SE) are adjusted for age and sex.
Physical activity score is based on a modified Paffenbarger questionnaire of the Harvard Alumni Activity Survey.