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. 2010 Dec;25(6):693–703. doi: 10.1089/cbr.2010.0820

FIG. 2.

FIG. 2.

Epidermal growth factor receptor-2 receptor binding properties of the radiolabeled 64Cu-DO3A-(GSG)-KCCYSL, 64Cu-CB-TE2A-(GSG)-KCCYSL, and 4Cu-NO2A-(GSG)-KCCYSL peptides. Approximately, 1.0 × 105 MDA-MB-435 breast carcinoma or normal mammary epithelial cells/tube were incubated at 37°C for different time intervals with 100,000 counts per minute radioligand. The radiolabled peptides bound to human MDA-MB-435 breast carcinoma cells. 64Cu-DO3A- peptide (•); 64Cu-CB-TE2A-peptide (▪) and 64Cu-NO2A- peptide (□).Very minimal or no binding was observed with normal mammary epithelial (184A1) cells using 64Cu-DO3A-peptide (▴) or 64Cu-CB-TE2A-peptide (♦) or 64Cu-NO2A- peptide (○), respectively.