Figure 7. NAC reduced vWF multimers in vivo in C57BL/6 mice.

(A) Wild-type C57BL/6 mice were injected intravenously with NAC at doses of either 0.4 or 0.8 mg/g. The higher dose had a markedly greater effect on vWF multimer size. The effect was time dependent. (B) Densitometry analysis of vWF multimer pattern on a 1.5% agarose gel. Top panel: overlay of densitometry curves of vWF multimers from mice treated with either saline (gray) or with 0.4 mg/g of NAC for 1 hour (red) or 2 hours (green).