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. 2011 Jan 4;121(2):569–581. doi: 10.1172/JCI42545

Figure 2. Aspirin enhances endogenous production of novel E-series resolvin precursors.

Figure 2

(A) Chiral HPLC-MS/MS analysis of E-series resolvin precursor stereoisomers from human serum. Healthy human sera, treated with or without aspirin, were collected (see inset) and 18S- and 18R-HEPE were separated by reverse-phase chiral column without derivatization and quantified by MRM, specific transition at 317→259. Results are from human subjects given aspirin; representative chromatogram of n = 3. (B) Tandem mass spectra and structural assignment of 18R-HEPE and 18S-HEPE from human serum.