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. 2011 Jan 25;6(1):e15973. doi: 10.1371/journal.pone.0015973

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A. Confocal images of a representative retinal microglia cell under control conditions (left), in the presence of bicuculline (150 µM)(middle), an antagonist of ionotropic GABA_A receptors, and during washout (right). Microglial dendritic morphology is slightly increased in size during stimulation with bicuculline, with partial recovery during washout. Scale bar = 20µm. B. Dendritic tree area and total dendritic length was slightly but significantly increased in the presence of bicuculline, while branch point number was unchanged (n = 53 cells). C. Conversely, application of GABA (1mM; n = 23 cells) exerted slight increases in total dendritic length and branch point number, but did not change dendritic tree area significantly. D. Overall process velocity was increased with GABAergic blockade with bicuculline and decreased with GABA application. All significant changes (p<0.05) are indicated by an asterisk (*).