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. 2011 Jan 25;6(1):e15973. doi: 10.1371/journal.pone.0015973

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A. Microglial morphologic parameters of dendritic tree area, total dendritic length, and branch point number were significantly decreased by the application of probenecid (1mM), an antagonist of pannexin-1 hemichannels; (n = 46 cells). B. Morphological parameters were similarly decreased with concurrent AMPA (1 mM) and probenecid (5mM) application, indicating that AMPA-induced ATP_release may be mediated significantly by pannexin-1 hemichannels. C. Overall microglial process velocity was similarly decreased with p probenecid (5mM) alone and with concurrent AMPA (1mM) and probenecid (5mM). All significant changes (p<0.05) from baseline are indicated by an asterisk (*).