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. 2011 Jan 25;6(1):e16141. doi: 10.1371/journal.pone.0016141

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Zúñiga et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The amino acid sequences of the regions involved in extracellular [H⁺] gating for these two K_2P channels are shown. Highlighted in gray are the pH_o-sensors R224 and H98 of TASK-2 and TASK-3 respectively, and also TASK-2 I89 that corresponds to the envioronment of R224. The signature sequences for the pore regions P1 and P2, left and right, are boxed.