Table III.

SNPs at 15q25 region and bladder cancer risk among NHW

	Cases/controls	Crude		Adjusted for smoking status in reference year, number of cigarettes smoked and number of years of smoking
		OR (95% CI)a	Pa	OR (95% CI)a	Pa
rs1051730
GG	182/244	1.00 (ref)		1.00 (ref)
GA	231/262	1.17 (0.90–1.52)	0.23	1.17 (0.88–1.54)	0.28
AA	65/63	1.40 (0.94–2.09)	0.093	1.45 (0.96–2.20)	0.081
Per A allele		1.18 (0.99–1.42)	0.072	1.19 (0.98–1.45)	0.072
rs8034191
TT	176/248	1.00 (ref)		1.00 (ref)
CT	234/259	1.25 (0.96–1.63)	0.090	1.27 (0.96–1.68)	0.088
CC	66/61	1.54 (1.04–2.30)	0.033	1.59 (1.04–2.42)	0.031
Per C allele		1.25 (1.04–1.50)	0.019	1.26 (1.04–1.54)	0.017
Per C allele of rs8034191 stratified by smoking status
Never-smokers	56/116b	1.22 (0.85–1.75)	0.29	1.22 (0.85–1.75)	0.29
Former smokers	120/148b	1.44 (1.06–1.95)	0.018	1.44 (1.06–1.95)	0.020
Current smokers	124/56b	1.15 (0.81–1.63)	0.45	1.08 (0.76–1.55)	0.66
P for interaction between rs8034191 and smoking statusc			0.58		0.56

^aResults were estimated from conditional logistic regression.

^bNumber of cases and controls carrying at least one C allele at rs8034191.

^cLikelihood ratio test of the interaction term between rs8034191 and three-category smoking status variable assuming a log-additive mode of risk for the C allele.