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Histopathology of colonic lesions in hCYP1A transgenic mice treated with 200 mg/kg PhIP and 1.5% DSS, sacrificed 6 weeks after PhIP administration. (A) normal colonic mucosa, (B) tubular adenomas, (C) polypoid tubular adenocarcinomas in colon with mucosal ulceration, (D) adenocarcinomas in colon with severe inflammation. Sections were stained with hematoxylin and eosin.
