Table III.

ORs (95% CIs) with the lowest P-values (P < 0.01) for genetic variants and CRC risk

Gene	Chr	Position (dbSNP b126)	SNP	MAFc	Genotype	Nd	Minimally adjusteda		Fully adjustedb
							OR (95% CI)	Ptrende	OR (95% CI)	Ptrende
ARNT	1	149068897	rs3215133	0.039	TT	464/574	1.0	0.02	1.0	0.009
					−/T or −/−	28/54	0.57 (0.35, 0.92)		0.50 (0.29, 0.84)
		149075513	rs2228099	0.398	CC	200/205	1.0	0.008	1.0	0.003
					GC	215/278	0.80 (0.62, 1.05)		0.72 (0.54, 0.95)
					GG	70/114	0.62 (0.44, 0.89)		0.58 (0.40, 0.85)
		149126810	rs12410394	0.480	GG	160/148	1.0	0.005	1.0	0.0008
					AG	227/294	0.73 (0.55, 0.97)		0.66 (0.48, 0.89)
					AA	105/159	0.62 (0.44, 0.87)		0.54 (0.37, 0.78)
CYP1A2	15	72834479	rs2470890	0.314	CC	266/293	1.0	0.006	1.0	0.003
					TC	166/216	0.78 (0.59, 1.03)		0.72 (0.53, 0.96)
					TT	60/93	0.57 (0.37, 0.87)		0.54 (0.34, 0.85)
		72849450	rs11072508	0.319	CC	264/292	1.0	0.005	1.0	0.00173
					TC	171/217	0.80 (0.60, 1.05)		0.70 (0.52, 0.94)
					TT	61/97	0.54 (0.35, 0.83)		0.52 (0.33, 0.82)
		72852697	rs4886410	0.319	CC	264/295	1.0	0.007	1.0	0.003
					GC	170/214	0.81 (0.61, 1.06)		0.72 (0.53, 0.96)
					GG	62/97	0.56 (0.36, 0.85)		0.54 (0.35, 0.85)

BMI, body mass index

^aAdjusted for the matching factors age, sex and race.

^bFurther adjusted for BMI 5 years before diagnosis, daily energy intake, pack-years of smoking, ever use of aspirin consecutively for 3 months, years of schooling, lifetime hours of physical activity, daily intake of calcium and daily intake of non-starch polysaccharides from vegetables. Sample size was reduced by 43 (23 controls/20 cases) due to missing values.

^cMAF in all CRC subjects combined.

^dNumber of cases/controls.

^eAfter multiple comparison adjustment, P-values < 0.0013 were considered statistically significant and P-values ≥ 0.00167 were non-significant. Note: none of these SNPs was significantly associated with adenoma (P-values > 0.05).