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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Neurobiol Aging. 2010 Oct 18;33(5):878–885. doi: 10.1016/j.neurobiolaging.2010.08.007

Figure 1. ROI-based analysis of the histopathological and imaging data.

Figure 1

Tissue section from the right hemisphere and the tissue block from the rostral middle frontal gyrus are displayed (A). 3D MRI is manually reoriented for anatomical matching to the tissue section and the region of interest (ROI) simulating the tissue block is manually placed on the MRI (B). The PiB retention ratio image and the registered ROI is shown (C). Correlations were performed between PiB retention ratio from the ROI (masked with the segmented gray matter and corrected for CSF partial volume averaging) and the Aβ, Lewy body α-synuclein and PHF-tau neurofibrillary tangle densities from the tissue block.

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