Table.

PiB retention ratio and the distribution and magnitude of AD and LB pathology in different brain regions of interest^*

	PiB retention ratio	Neuritic plaques**	Diffuse plaques**	Amyloid load	NFT density	LB density
Diagnostic regions
Midfrontal	1.92	5	16	0.09	0.02	2.41
Middle temporal gyrus	1.50	5	11	0.07	0.02	2.48
Entorhinal cortex***	N/A	3	15	0.06	4.3	3.32
Middle hippocampus	1.00	0	0	0.007	13.25	N/A
Inferior parietal	1.62	4	13	0.06	0	0.46
Caudate	1.29	N/A	N/A	0.03	0	N/A
Putamen	1.44	N/A	N/A	0.03	0	N/A
Thalamus	1.24	N/A	N/A	0.01	0.03	N/A
Substantia nigra***	N/A	N/A	N/A	0.01	0	4.56
Anterior cingulate gyrus	1.94	6	22	0.07	0.03	6.53
Additional regions
Middle frontal gyrus	1.85	11	16	0.11	0.01	2.93
Amygdala	1.28	25	6	0.04	2.4	6.06
Precentral gyrus	1.70	9	11	0.04	0	0.57
Posterior hippocampus	1.24	0	0	0.007	19.57	N/A
Superior temporal gyrus	1.45	7	10	0.05	0	1.39
Posterior cingulate gyrus	1.83	8	10	0.08	0.125	2.34
Precuneus	1.95	5	12	0.1	0	1.89
Superior parietal lobule	1.98	12	11	0.08	0.009	1.33
Calcarine cortex	1.38	3	1	0.02	0	0.08

^*N/A = not applicable;

^**Plaque counts correspond to CERAD as follows: 1-5 = sparse; 6-19 = moderate; ≥20 = frequent (see text for description of pathology methodology)

^***Entorhinal cortex and substantia nigra regions evaluated at autopsy were not analyzed in the PiB-PET images because the sizes of the histological blocs were less than the resolution of PET in at least one dimension which did not allow reliable assessment of these regions.