Table 1.
All Subjects | Histological gastric GVHD | Clinical GI GVHD | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
never | at least once | never | at least once | |||||||
total n= | 60 | 4 | 56 | 6 | 54 | |||||
median | range | median | range | median | range | median | range | median | range | |
Age | 54 | 21–74 | 54 | 36–60 | 53 | 21–74 | 54 | 40–62 | 53 | 21–74 |
Day of GVHD onset | n/a | n/a | n/a | n/a | 35 | 11–976 | n/a | n/a | 36 | 11–986 |
n | % | n | % | n | % | n | % | n | % | |
Males | 35 | 58% | 4 | 100% | 31 | 55% | 5 | 83% | 30 | 56% |
Myeloablative Conditioning | 46 | 77% | 2 | 50% | 44 | 79% | 3 | 50% | 43 | 80% |
Donor: | ||||||||||
Related | 21 | 35% | 0 | 0% | 21 | 38% | 1 | 17% | 20 | 37% |
Unrelated, HLA-Matched | 22 | 37% | 1 | 25% | 21 | 38% | 2 | 33% | 20 | 37% |
Unrelated with HLA-mismatch | 17 | 28% | 3 | 75% | 14 | 25% | 3 | 50% | 14 | 26% |
Indication for HCT: | ||||||||||
Acute Leukemia | 32 | 53% | 2 | 50% | 30 | 54% | 3 | 50% | 29 | 54% |
Chronic Leukemia | 8 | 13% | 1 | 25% | 7 | 13% | 0 | 0% | 8 | 15% |
Lymphoma | 3 | 5% | 1 | 25% | 2 | 4% | 1 | 17% | 2 | 4% |
Myeloma | 3 | 5% | 0 | 0% | 3 | 5% | 1 | 17% | 2 | 4% |
MDS | 11 | 18% | 0 | 0% | 11 | 20% | 0 | 0% | 11 | 20% |
Myelofibrosis | 1 | 2% | 0 | 0% | 1 | 2% | 0 | 0% | 1 | 2% |
Aplastic Anemia | 2 | 3% | 0 | 0% | 2 | 4% | 1 | 17% | 1 | 2% |
Other GVHD sites: | ||||||||||
Skin | 25 | 42% | 3 | 75% | 22 | 39% | 4 | 67% | 18 | 33% |
Liver | 4 | 7% | 0 | 0% | 4 | 7% | 0 | 0% | 4 | 7% |
GI GVHD prohylaxis: | ||||||||||
CNI + MMF | 20 | 33% | 2 | 50% | 18 | 32% | 4 | 67% | 16 | 30% |
CNI + MTX | 37 | 62% | 1 | 25% | 36 | 64% | 2 | 33% | 35 | 65% |
CNI + MMF + Rapa | 3 | 5% | 1 | 25% | 2 | 4% | 0 | 0% | 3 | 6% |
Abbreviations: GVHD: graft versus host disease. GI: gastrointestinal. HLA: human leucocyte antigen. HCT: hematopoietic cell transplant. MDS: myelodysplastic syndrome. CNI: calcineurin inhibitor. MMF: mycophenolate mofetil. MTX: methotrexate. Rapa: rapamycin.