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. Author manuscript; available in PMC: 2011 Jan 26.
Published in final edited form as: Mol Cancer Ther. 2009 May 5;8(5):1250–1260. doi: 10.1158/1535-7163.MCT-08-1026

Figure 1.

Figure 1

DMDA-PatA has broad anticancer activity in vitro. A, chemical structures of pateamine A and DMDA-PatA. B, in vitro cell growth inhibition in human cancer cell lines. Human cancer cell lines were incubated in the presence of different concentrations of DMDA-PatA (0.3 nmol/L-10 μmol/L) or vinblastine (0.03 nmol/L-1 μmol/L) or DMSO-containing vehicle as control for 4 d. Methods of evaluation of cell growth are presented in Materials and Methods. IC50 values were calculated as the concentration of a test compound resulting in cell growth equal to 50% of DMSO control treated cell preparations.