Figure 1. Variations in striatal BDNF levels and body weight with aging in Bdnf+/− vs. WT mice.
(A) BDNF protein levels were lower in Bdnf+/− than WT littermates at all ages tested with no significant effect of age. (B) Body weight (grams) depended on a Genotype × Age interaction. Post-hoc analysis indicated body weight increases for both genotypes between 3 and 12 months of age (*p≤ 0.05). At 21 months of age, Bdnf+/− mice weighed more than age-matched WT mice (#p≤ 0.01) and more than 12-month-old Bdnf+/− mice (¶p≤ 0.01).