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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Genes Brain Behav. 2010 Oct 19;10(2):186–198. doi: 10.1111/j.1601-183X.2010.00654.x

Table 1.

Numbers of animals used in each assay.

Assays 3 month WT 3 month Bdnf+/− 12 month WT 12 month Bdnf+/− 21 month WT 21 month Bdnf+/−
BDNF levels# 9 8 8 12 5 6
Body weight# 10 10 10 9 11 9
Horizontal activity# 6 6 11 10 11 9
Vertical activity# 6 6 11 10 11 9
Accelerating rotarod# 8 5 11 10 11 9
Immunohistochemistry# 5 6 5 5 5 4
Microdialysis$ 7 7 7 5 ND ND
Striatal DAT activity 12 18 15 18 18 18
Striatal VMAT2 activity§ 4 4 4 4 6 6
#

Separate cohort for 3, 12 and 21 month-old WT and Bdnf+/− mice were used. Following completion of behavioral assays, brain tissues were used for immunohistochemistry and BDNF assays.

$

Separate cohort for 3 and12 month-old WT and Bdnf+/− mice were used.

Separate cohort for 3, 12 and 21 month-old WT and Bdnf+/− mice were used. DAT activity was determined from striatum of individual animals

§

Separate cohort for 3, 12 and 21 month-old WT and Bdnf+/− mice were used. Synaptic vesicles were prepared from pooled striatal tissue derived from three age and genotype matched animals (n=1).

ND: Not determined