Table 3.

The ADH1C haplotype block: haplotype frequencies in alcoholics and controls

Haplotype	PIains Indians		Southwest Indians		Finnish Caucasians		African Americans
	AD	Controls	AD	Controls	AD	Controls	AD	Controls
12112	0.45	0.49	0.56	0.50	0.20	0.22	0.36	0.34
21212	0.03	0.05	0.09	0.14	0.01
21222	0.44	0.39	0.31	0.32	0.50	0.50	0.16	0.14
12111	0.08	0.07	0.04	0.04	0.30	0.28	0.48	0.51
ADH1C*1 21	0.53	0.56	0.60	0.54	0.50	0.50	0.84	0.85
ADH1C*2 12	0.44	0.39	0.31	0.32	0.50	0.50	0.16	0.14
§N	452	220	632	144	464	388	534	844

The table lists haplotypes that have a frequency ≥ 5% in at least one population.

^§N: the number of haplotypes. AD = alcohol dependence Markers in the ADH1C haplotypes are from left to right: SNP27 to SNP31 (as listed in Table 1)..

Markers in ADH1C*1 and ADH1C*2 are: SNP28 (rs1693482 Gln272Arg) and SNP30 (rs698 Ile350Val).

The ADH1C*1 21 haplotype: Arg272, Ile350.

The ADH1C*2 12 haplotype: Gln272, Val350,.