Table 5.

Haplotype blocks across ALDH1A1: haplotype frequencies in alcoholics and controls

Haplotype	Plains Indians		Southwest Indians		Finnish Caucasians		African Americans
	AD	Controls	AD	Controls	AD	Controls	AD	Controls
Block1
222	0.59	0.65	0.56	0.52	0.45*	0.38	0.12	0.10
211	0.02	0.01	0.03	0.01	0.01	0.02	0.05**	0.02
122	0.02				0.01*	0.03	0.04	0.06
112	0.02	0.04			0.03	0.03	0.12	0.13
111	0.33	0.27	0.34	0.40	0.44	0.47	0.64	0.63
Block2
21	0.68	0.69	0.49	0.42	0.55*	0.47	0.23	0.24
22	0.02				0.03	0.05	0.33	0.34
12	0.29	0.28	0.50	0.56	0.42	0.48	0.44	0.42
Block3
1222221	0.68	0.71	0.56	0.48	0.61	0.56	0.17	0.13
1212221	0.01		0.01	0.01	0.10	0.11	0.04	0.05
2212221		0.01			0.03*	0.05	0.14	0.16
2211112	0.01		0.01		0.13	0.14	0.08	0.09
2111112	0.24	0.25	0.40*	0.51	0.10	0.06	0.20	0.19
2212112							0.06	0.07
2212121							0.09	0.09
1211112							0.05	0.03
1222111							0.03	0.05
Block4
21	0.72	0.76	0.63	0.59	0.67	0.63	0.52	0.51
22		0.01	0.01	0.01	0.06	0.09	0.38	0.40
12	0.28	0.22	0.37	0.40	0.26	0.27	0.10	0.09
§N	452	218	630	144	462	388	534	844

The table lists haplotypes that have a frequency ≥ 5% in at least one population.

^§N: the number of haplotypes. AD = alcohol dependence

^*p value <0.05

^**p<0.01.

The numbering of SNPs corresponds to Table 1: Block 1: SNP41-43; Block 2: SNP44-45; Block 3: SNP47-49, 51-54; Block 4: SNP55-56. The bolded numbers indicate the frequencies of the yin yang haplotypes.