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. Author manuscript; available in PMC: 2011 Jan 26.
Published in final edited form as: Biochem J. 2010 Jan 27;426(1):19–29. doi: 10.1042/BJ20090813

Figure 3. Parent peptide and NBD1 domain structure.

Figure 3

The peptides used for the experiment in Figure 1 encompass a region of CFTR NBD1 centred on an exposed loop bridging two helices [32], also including two short ‘wings’ belonging to these helices (left). The w.t. peptide of Figure 2 is shown at the bottom. The parent peptide (peptide number 1 in Figure 2) belongs to the NBD1 domain of CFTR schematically represented in the right cartoon (in practice, the two NBDs are thought to create a dimeric sandwich trapping two nucleotides).