Table 3.
Olfactory function by Sniffin' sticks and PSG study in patients with PARK2 mutation, controls, and Parkinson's disease.
| Case | 1 | 2 | 3 | 4 | 5 | 6 | PARK2 total (n = 6) | Control (n = 10) | Parkinson's disease (n = 15) |
|---|---|---|---|---|---|---|---|---|---|
| Age | 71 | 55 | 46 | 41 | 38 | 36 | 47.8 ± 13.2 | 46.0 ± 15.3 | 69.6 ± 6.6 |
| Sniffin' sticks Test | |||||||||
| Threshold test | 4.5 | 6.3 | 6.3 | 5.8 | 5.0 | 9.0 | 6.1 ± 1.6 | 8.0 ± 1.3* | 2.2 ± 2.3** |
| Discrimination test | 8.0 | 9.0 | 12.0 | 14.0 | 9.0 | 8.0 | 10.0 ± 2.4 | 11.9 ± 2.4 | 6.1 ± 2.5 |
| Identification test | 1.0 | 13.0 | 10.0 | 14.0 | 13.0 | 10.0 | 10.1 ± 4.8 | 10.9 ± 2.0 | 5.1 ± 1.8 |
| PSG findings | |||||||||
| Apnea index (times/H) | 10.1 | 22.5 | 1.2 | 0.4 | 1.0 | 2.1 | |||
| Hypopnea index (times/H) | 2.2 | 14.0 | 4.7 | 0.3 | 1.9 | 9.4 | |||
| Apnea Hypopnea index (times/H) | 12.3 | 36.5 | 5.9 | 0.8 | 3.0 | 11.4 | |||
| Arousal index (times/H) | 16.0 | 39.8 | 37.7 | 13.4 | 14.3 | 11.1 | |||
| Respiratory arousal index (times/H) | 5.5 | 27.3 | 4.6 | 0.2 | 1.6 | 3.3 | |||
| PLM index(times/H) | 7.8 | 0.0 | 7.7 | 0.0 | 29.5 | 0.0 | |||
| PLM arousal index(times/H) | 0.0 | 0.0 | 5.3 | 0.0 | 2.8 | 0.0 | |||
| REM sleep twitching on TA muscle | − | + | − | + | − | − | |||
H/M: theheart to mediastinum uptake ratio, NE: not examined.
PLM: periodic limb movements, TA: tibialis anterior.
*t-test: compared with PARK2 patients P < .05.
**t-test: compared with PARK2 patients and control P < .01.