Skip to main content
. 2010 Jan 13;1(3):224–230. doi: 10.4161/nucl.1.3.11250

Figure 1.

Figure 1

Pathways that facilitate nuclear export of intron-containing pre-tRNAs and nuclear re-export of retrogradely transported spliced tRNAs in S. cerevisiae. Genetic studies suggest that nuclear export of intron-containing pre-tRNAs is facilitated by Los1p (I) and an unidentified nuclear export receptor (II) (A). Upon completion of tRNA splicing in the cytoplasm, the spliced tRNAs are returned to the nucleus possibly by Mtr10p for reasons that are not understood (B). The re-imported spliced tRNAs are aminoacylated in the nucleolus and re-exported by at least three pathways named Utp9p-dependent and Msn5p-dependent (I), Utp9p-dependent and Msn5p-independent (II) Utp9p-independent and Los1p-dependent (III) (C).