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. 2010 Feb 8;1(3):231–236. doi: 10.4161/nucl.1.3.11443

Figure 2.

Figure 2

Nucleocytoplasmic regulation of microtubule-associated proteins. Model illustrating how microtubule-associated proteins in fission yeast are regulated in a spatiotemporal manner. Alp7/TACC-Alp14/TOG and Klp5-Klp6 (kinesin-8s) are targets of Ran in fission yeast and undergo nucleocytoplasmic shuttling during the cell cycle. Alp7-Alp14 is retained in the mitotic nucleus through inhibition of nuclear export by the cyclin-dependent kinase 1 (CDK1). See text for Klp5-Klp6 and Ase1. ‘I’ represents the destination of the protein in interphase, whereas ‘M’ is the destination in mitosis.