Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed model of EXPAND1 in chromatin structure regulation. (A) EXPAND1 associates with chromatin through its ability to interact with nucleosomes. (B) DNA damage triggers the accumulation of EXPAND1 to sites of DNA breaks. (C) Binding of EXPAND1 to chromatin domains surrounding DNA break site opens up its structure. (D) Efficient loading of DNA repair proteins to the damage-modified chromatin. For simplicity, 53BP1 is omitted from illustration (see text).
