Table 3.
Factors associated with nutrition programme failure among HIV-infected adults treated in Kenya and Uganda, 2006-2008
| Factors | Adjusted (Model 1) | Adjusted (Model 2) | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Treatment cohort | ||||
| Arua | 1.0 | 0.01 | 1.0 | 0.007 |
| Homa Bay | 1.5 (1.0-2.3) | 1.7 (1.1-2.4) | ||
| Mathare | 0.7 (0.4-1.0) | 0.8 (0.5-1.1) | ||
| Period of admission in the NP | ||||
| Years 2005 - 2006 | 1.0 | 0.1 | 1.0 | 0.1 |
| January-June 2007 | 0.8 (0.5-1.2) | 0.8 (0.6-1.2) | ||
| July 2007-June 2008 | 1.1 (0.8-1.6) | 1.1 (0.8-1.2) | ||
| In the HIV programme | ||||
| Patients already in care | 1.0 | 0.5 | 1.0 | 0.5 |
| New patients | 1.1 (0.8-1.6) | 1.1 (0.8-1.6) | ||
| Age at NP admission, years | ||||
| ≥45 | 1.0 | 0.2 | 1.0 | 0.4 |
| 30-44 | 1.0 (0.6-1.5) | 1.0 (0.6-1.4) | ||
| 15-29 | 0.7 (0.4-1.2) | 0.8 (0.5-1.2) | ||
| Gender | ||||
| Women | 1.0 | 0.001 | 1.0 | 0.001 |
| Men | 1.6 (1.2-2.1) | 1.5 (1.2-2.0) | ||
| Malnutrition at admission | ||||
| Moderate | 1.0 | <0.0001 | 1.0 | <0.0001 |
| Severe | 2.2 (1.7-3.0) | 2.2 (1.7-2.8) | ||
| Recorded clinical diagnoses | ||||
| TB at NP admission | 0.9 (0.6-1.3) | 0.7 | 0.9 (0.6-1.3) | 0.6 |
| TB diagnosed during NP follow up | 1.0 (0.7-1.4) | 0.9 | 1.0 (0.7-1.4) | 0.9 |
| Extensive candidiasis at NP admission | 1.4 (0.6-3.4) | 0.4 | 1.2 (0.5-2.6) | 0.7 |
| Diarrhoea at NP admission | 1.3 (0.8-2.0) | 0.3 | 1.3 (0.8-2.0) | 0.3 |
| ART status at admission | ||||
| On ART | 1.0 | <0.0001 | 1.0 | <0.0001 |
| Eligible but never started on ART | 6.2 (3.5-11.1) | 4.5 (2.7-7.7) | ||
| Eligible & ART initiated at or after NP admission | 0.5 (0.3-0.8) | 0.6 (0.4-0.9) | ||
| Ineligible for ART | 1.4 (0.9-2.3) | 1.6 (1.0-2.5) | ||
Model 1: Results from analysis where deaths, lost to follow up and uncured were classified as NP failure; and patients with NP outcome defined as "other" were excluded from the model.
Model 2: Results from analysis where deaths, lost to follow up, uncured, patients with intolerance to RUTF and those who stopped nutritional therapy for other reasons were classified as "programme failure".
ART - antiretroviral therapy; NP - nutrition programme; OR - odds ratio; TB - tuberculosis