Table 2.
Multivariate analysis of VEGF and MVD expression in NSCLC specimens
| VEGF expression | MVD expression | |||||
|---|---|---|---|---|---|---|
| β | HR (95% CI) | P | β | HR (95% CI) | P | |
| COX-2 expression | ||||||
| High | 2.286 | 9.836 (3.387 - 28.564) | 0.000 | 1.146 | 3.147 (1.152 - 8.598) | 0.025 |
| Low | 1.000 | 1.000 | ||||
| TNM stage | ||||||
| III + IV | 0.061 | 1.063 (0.493 - 2.289) | 0.877 | 0.025 | 1.025 (0.493 - 2.132) | 0.947 |
| I + II | 1.000 | 1.000 | ||||
| Histology | ||||||
| Adeno | -0.300 | 0.741 (0.303 - 1.810) | 0.510 | 0.400 | 1.491 (0.649 - 3.425) | 0.346 |
| SCC | 1.000 | 1.000 | ||||
| Differentiation | ||||||
| Poor | -0.292 | 0.746 (0.198 - 2.809) | 0.665 | -0.969 | 0.379 (0.106 - 1.359) | 0.137 |
| Well and moderate | 1.000 | 1.000 | ||||
| Smoking | ||||||
| Yes | -0.775 | 0.461 (0.145 - 1.461) | 0.188 | -0.481 | 0.618 (0.214 - 1.785) | 0.374 |
| No | 1.000 | 1.000 | ||||
| Sex | ||||||
| Male | -1.005 | 0.366 (0.101 - 1.330) | 0.127 | -0.511 | 0.600 (0.170 - 2.110) | 0.426 |
| Female | 1.000 | 1.000 | ||||
| Age | ||||||
| ≥ 60 yrs | 0.316 | 1.371 (0.413 - 4.551) | 0.606 | -0.223 | 0.800 (0.251 - 2.551) | 0.706 |
| < 60 yrs | 1.000 | 1.000 | ||||
Abbreviations: HR, hazard ratio; CI, confidence interval of the estimated HR; Adeno, adenocarcinoma; SCC, squamous cell carcinoma