Table 6.

Results from selected series regarding late toxicity in head and neck cancer patients treated with RT ± chemotherapy

Technique	Authors [reference]	year	No of patients	median follow up (months)	stage lll/lV (%)	Chemotherapy (%)	grade 3/4 late toxicity
	Chao et al [25]	2003	74	30	93	23	0
I
	de Arruda et al [14]	2006	50	18	92	86	3 (6%)
M
	Lee et al [17]	2006	41	31	100	100	5 (12%)
R
	Studer et al [1]	2006	115	18	52	78	18 (15%)
T
	present study	2010	81*	55	100	85	7 (9%)
	Denis et al [26]	2003	44	60	100	61	30 (68%)
3D-CRT
	Huguenin et al [19]	2004	224	39	97	50	G3: 92 (41%)
							G4: 5 ("%)

Abbreviations: IMRT: Intensity modulated radiation therapy; 3D-CRT: three-dimensional conformal radiotherapy (*patient with previous Cobalt radiation therapy excluded)