Skip to main content
. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Eur Respir J. 2009 Dec 23;36(2):428–437. doi: 10.1183/09031936.00145309

Figure 1. Schematic of the chromosome 17 congenic segments for 2R, 4R, 5R, and C3H-H2b mice that were used to reduce inflammation 2 (Inf2).

Figure 1

The congenic segments are shown with respect to Inf2 (on left). The red rectangle represents the reduced Inf2. Mouse genes and human homologues and their chromosomal locations within the reduced Inf2 are shown at right. While most of the genes are in the same order in both species, some are not. These locations were identified using the MGI website:http://www.informatics.jax.org/searches/marker website and NCBI. The yellow highlighted genes are major histocompatibility complex (MHC) class II genes and TNF cluster genes identified as candidate genes using proof of concept experiments (see Figs. 5 and 6). Abbreviations:Ager, advanced glycosylation end product-specific receptor; Agpat1; 1-acylglycerol-3-phosphate O-acyltransferase 1; Aif1, allograft inflammatory factor 1; Atf6b, activating transcription factor 6 beta; Bat5, HLA-B associated transcript 5; Btnl2, butyrophilin-like 2; Btnl1, butyrophilin-like 1; C2, complement component 2; C4a, complement component 4A; C4b, complement component 4B; Cfb, complement factor B; CREBL1, cAMP responsive element binding protein-like 1; Cyp21a1, cytochrome P450, family 21, subfamily a, polypeptide 1; Cyp21a2-ps, cytochrome P450, family 21, subfamily a, polypeptide 2 pseudogene; Ddah, dimethylarginine dimethylaminohydrolase 2;Egfl8, EGF-like domain 8; Ehmt2, euchromatic histone-lysine N-methyltransferase 2; Fkbpl, FK506 binding protein-like; Gpsm3, G-protein signalling modulator 3; H2-Ab1, class II antigen A, beta 1; H2-Aa, class II antigen A, alpha; H2-Eb1, class II antigen E beta; H2-Eb2, class II antigen E beta 2; H2-Ea, class II antigen E alpha; H2-ob, O region beta locus; Hspa1b, heat shock 70kDa protein 1B; Hspa1a, heat shock 70kDa protein 1A; Lsm2, LSM2 homolog; Lta, lymphotoxin a; Ltb, lymphotoxin b; Ly6g6c, lymphocyte antigen 6 complex, locus G6C; Ly6g5c, lymphocyte antigen 6 complex, locus G5C; Msh5, mutS homolog 5;Neu1, neuraminidase1; Notch4, notch gene homolog 4; Pbx2, pre B-cell leukemia transcription factor 2; Ppt2, palmitoyl-protein thioesterase 2; Prrt1, proline-rich transmembrane protein 1; Psmb8, proteosome subunit, beta type 8; Rdbp, RD RNA-binding protein; Rnf5, ring finger protein 5; Slc44a4; solute carrier family 44, member 4; Stk19, serine/threonine kinase 19;Tap-1, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); Tap-2, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Tnf, tumor necrosis factor; Tnxb, tenascin B; Vars, valyl-tRNA synthetase; Zbtb12, zinc finger and BTB domain containing 12. No human homolog exists for Btnl1.