Table 1.
Mean + SD pO2 and hypoxic fraction (HF5, percentage voxels with pO2 < 5 Torr) for individual tumors with respect to hyperoxic gas challenge in the sequence: air–oxygen–air
| Intervention |
||||||
|---|---|---|---|---|---|---|
| Air (baseline) |
Oxygen |
Air (return) |
||||
| Tumor number and size (cm3) | pO2 (Torr) | HF5 (%) | pO2 (Torr) | HF5 (%) | pO2 (Torr) | HF5 (%) |
| 1 (1.2) | 11.5 ± 3.2 | 50 | 9.1 ± 16.9 | 72 | 9.8 ± 11.2 | 33 |
| 2 (10.3) | –0.5 ± 1.2 | 70 | 69 ± 7.6* | 2** | 11.4 ± 1.8* | 42** |
| 3 (10.8) | 3.6 ± 1.0 | 71 | 6.9 ± 0.1* | 45* | 3.2 ± 2.7 | 58 |
| 4 (3.7) | 12.7 ± 1.4 | 38 | 16.6 ± 3.2 | 54 | 8.6 ± 1.1 | 57 |
| 5 (9.1) | 32.7 ± 4.7 | 56 | 49.2 ± 4.9** | 60 | 26.6 ± 0.6 | 58 |
| 6a (5.6) | 40.5 ± 2.7 | 0 | 318 ± 6** | 0 | 39.7 ± 2.0 | 0 |
| Mean ± SD (n = 6) | 17 ± 16 | 48 ± 26 | 78 ± 120* | 39 ± 31 | 17 ± 14* | 41 ± 23 |
| Mean ± SD (n = 5, Nos 1–5) | 12 ± 12 | 57 ± 14 | 30 ± 27** | 47 ± 27 | 12 ± 19* | 50 ± 12 |
For individual tumors, mean pO2 or HF5 was compared between baseline air breathing and the last two measurements with oxygen breathing or return to air.
*
P < 0.05.
**
P < 0.01.
a
Tumor 6 showed unusually high pO2 and response, and comparison of the 1H anatomical (H2O) and selective HMDSO MR images showed that HMDSO had been deposited in the tumor periphery.