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. 2011 Jan 26;6(1):e16380. doi: 10.1371/journal.pone.0016380

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–C) IgG extravasations in blood vessels in GCL. (D–F) IgG extravasations in blood vessels in OPL. In non-ischemic control retina, IgG staining was confined inside the blood vessel lumen demarcated by endothelial cells (arrows in A & D). However, I/R induced blood vessel leakage in both GCL and OPL (arrow heads in B & E) in the vehicle-treated I/R retina but not in the LBP-treated I/R retina (arrows in C & F). (G, H) Quantification of blood vessel leakage in GCL (G) and OPL (H). More leaky blood vessels were observed in GCL (G) and OPL (H) of the vehicle-treated I/R retina. However, LBP treatment decreased the I/R-induced blood vessel damage, evident from fewer leaky blood vessels. ^###p<0.001 vs. non-ischemic control retina; **p<0.01, ***p<0.001 vs. vehicle-treated I/R retina. Scale bar, 25 µm.