Figure 2.

Family tree. Circles represent women, squares represent men. In family members at risk for mitochondrial disorder the date of birth and, if appropriate, date of death are indicated. Fully or partially filled symbols represent individuals showing disease-specific symptoms and each closed quarter stands for a single clinical manifestation: the upper quarter for diabetes mellitus; the right quarter for cardiomyopathy; the lower quarter for hearing loss; the left quarter for neuropsychiatric disorder. The question mark stands for death of unknown origin at young age. The fully filled circle represents our index patient.