Skip to main content
. 2011 Jan 26;6(1):e16540. doi: 10.1371/journal.pone.0016540

Figure 4. Effect of dihydropyridines on the contractile response of the uterine artery to ET-1.

Figure 4

ET-1 concentration was cumulatively increased (0.1 nM–0.1 µM) with or without a 10-minute pre-incubation period with a DHP. (A) Representative recordings of isometric responses. (B) Dose response curves obtained for ET-1 in the absence (❍) or in the presence of nifedipine (1 µM,☐) or nicardipine (1 µM,▪). Data, expressed as a percentage of the contraction induced by Phe in the same experiment, indicate the means ± S.E.M. of 10 different arteries with experiments performed in triplicate. **p<0.001, ***p<0.0001.