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. 2011 Jan 26;6(1):e16497. doi: 10.1371/journal.pone.0016497

Figure 4. Altered adaptive responses to a novel environment in Slitrk6-KO mice.

Figure 4

(A, B) Open field test. (A) The total distance moved was less in Slitrk6-KO than in WT mice (left). The distance moved in the first 5 min of the test was significantly lower in Slitrk6-KO mice (right). (B) In Slitrk6-KO mice, the total time spent in the center area was greater than that of the WT (left) and was significantly increased in the first 5 min of the test (right). (C–G) Hole-board test. There were no significant differences in distance moved (C), number of rearing episodes (D), and number of head dips (E) between Slitrk6-KO and WT mice. Duration per head dip was significantly decreased in Slitrk6-KO mice (F). Latency time to head dip was significantly decreased in KO mice (G). Values are mean ± standard error of the mean. *P<0.05, **P<0.01 for Mann-Whitney's U-test (B, center area data) or Student's t-test (others). WT, n = 10; KO, n = 10.