Table 1.
TTX downregulated genes
| Definition | Z ratio |
|
|---|---|---|
| 7 DIV vs. control | 3 DIV vs. control | |
| Somatostatin (Sst) | −10.49 | −9.09 |
| Neuropeptide Y (npy) | −8.16 | −7.09 |
| Glutamate decarboxylase 1 (Gad1) | −7.58 | −6.68 |
| Neurogranin (Nrgn) | −7.54 | −3.78 |
| Solute carrier family 32 (GABA vesicular transporter), member 1 (Slc32a1) | −6.46 | −4.48 |
| Thymus cell antigen 1, theta (Thy1) | −5.65 | −3.79 |
| Similar to cyclin-dependent kinase 5 activator isoform p39 precursor (LOC5011) | −5.18 | −3.91 |
| Brain-enriched SH3-domain protein Besh3 (Besh3) | −4.42 | −3.77 |
| NEL-like 1 (chicken) (Nell1) | −4.06 | −2.84 |
| Similar to contains transmembrane (TM) region (predicted) (LOC361560) | −3.99 | −3.25 |
| Eukaryotic translation elongation factor 1 alpha 2 (Eef1a2) | −3.91 | −1.13 |
| Gamma-aminobutyric acid A receptor, alpha 5 (Gabra5) | −3.84 | −3.48 |
| Famesyl diphosphate famesyl transferase 1 (Fdft1) | −3.8 | −3.58 |
| Neuropilin (NRP) and tolloid (TLL)-like 2 (predicted) (Neto2_predicted) | −3.78 | −3.22 |
| Calbindin 1 (Calb1) | −3.76 | −4.51 |
| Similar to Ca2+-dependent activator for secretin protein 2 (LOC312166) | −3.62 | −4.55 |
| IQ motif and Sec7 domain 3 (lqsec3) | −3.61 | −4.08 |
| Rho GDP dissociation inhibitor (GDI) gamma (predicted) (Arhgdig_predicted) | −3.6 | −2.89 |
| 3-hydroxy-3methylglutaryl-Coenzyme A synthase 1 (Hmgcs1) | −3.58 | −3.4 |
| Reelin (Reln) | −3.48 | −4.55 |
| Visinin-like 1 (Vsnl1) | −3.46 | −4.92 |
| Chimerin (chimaerin) 1 (Chn1) | −3.46 | −3.3 |
| Calcium/calmodulin-dependent protein kinase II inhibitor 1 (Camk2n1) | −3.44 | −0.71 |
| Stathmin-like 3 (Stmn3) | −3.37 | −0.86 |
| Calcium/calmodulin-dependent protein kinase II beta subunit (Camk2b) | −3.35 | −2.38 |
| Growth associated protein 43 (Gap43) | −3.29 | −0.52 |
| N-myc downstream regulated 4 (Ndr4) | −3.27 | −2.25 |
| Similar to TAFA1 protein (LOC500266) | −3.26 | −2.94 |
| ATPase, H+ transporting, V1 subunit G isoform 2 (Atp6v1g2) | −3.24 | −2.66 |
| Ubiquitin carboxy-terminal hydrolase L1 (Uchl1) | −3.23 | −1.92 |
The most strongly downregulated genes after 7 days of TTX treatment ranked according to their Z ratio. Z ratios after 3 days of TTX treatment are listed for comparison.
Key: DIV, days in vitro; TTX, tetrodotoxin.