Fig. 3.

KEGG pathway reconstructions reveal metabolic functions that are enriched or underrepresented in the human distal gut microbiome as follows: both samples compared with all sequenced bacterial genomes in KEGG (blue), the human genome (red), and all sequenced archaeal genomes in KEGG (yellow). Asterisks indicate enrichment (odds ratio > 1, P < 0.05) or underrepresentation (odds ratio < 1, P < 0.05). The KEGG category, “metabolism of other amino acids,” includes amino acids that are not incorporated into proteins, such as β-alanine, taurine, and glutathione. Odds ratios are a measure of relative gene content based on the number of independent hits to enzymes present in a given KEGG category.