Figure 2.

(A) There is strong expression of MUC6 in the glands of the pyloric gland adenoma (MUC6 ×40). In some areas of the polyp, the glands positive for MUC6 also show patchy co-expression of MUC5AC (circled area, compare with circled area in figure 2B). (B) There is expression of MUC5AC either restricted to surface epithelium with lack of staining within the glands of the pyloric gland adenoma or with patchy co-expression within the glands of the pyloric gland adenoma (circled area) (MUC5AC ×40). (C) A high proliferation index is shown within areas of high-grade dysplasia (MIB-1 ×200). (D) Typical glands of pyloric gland adenoma negative for p53 (p53 pyloric gland adenoma ×400, inset p53 pyloric gland adenoma high-grade dysplasia/intramucosal adenocarcinoma ×400). Area of high-grade dysplasia/intramucosal adenocarcinoma with moderate to strong nuclear staining for p53 (inset).