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Action potential duration alternans induced by Ito. (A) APD alternans from a canine epicardial myocyte under “simulated ischemia” condition (Lukas and Antzelevitch, 1993). (B) APD alternans from the LR1 model with an Ito added. PCL = 800 ms which is the same as in the experiment in A. (C) ECG from a patient with Brugada syndrome showing TWA (Nishizaki et al., 2005).
