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The EP receptor intracellular signaling pathway and its effects on HFL-1 cell migration. PGE2 binds EP1, EP2, EP3, and EP4 receptors, and can either stimulate or inhibit cell migration. AC, adenylyl cyclase; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; PI3K, phosphatidylinositol-3–kinase; solid line, established signal pathway; dotted line, possible signaling pathway; ↓, inhibit; ↑, stimulate.
