TABLE 2.
Liver amino acid levels (μM) in Gcgr+/+ and Gcgr−/− mice
| Normal |
Insulin deficiency |
|||
|---|---|---|---|---|
| Gcgr+/+ | Gcgr−/− | Gcgr+/+ STZ | Gcgr−/− STZ | |
| Ala | 246.10 ± 51.36* | 487.51 ± 58.13* | 359.31 ± 123.78 | 327.45 ± 42.27 |
| Ser | 145.86 ± 4.77* | 232.16 ± 11.87*‡ | 158.80 ± 14.46 | 195.02 ± 9.07‡ |
| Glx | 232.33 ± 30.40* | 554.39 ± 62.84* | 308.27 ± 30.97† | 526.43 ± 23.00† |
| Pro | 21.64 ± 2.01* | 30.59 ± 1.32*‡ | 30.54 ± 5.47 | 25.79 ± 0.100‡ |
| Phe | 20.01 ± 0.91* | 26.48 ± 1.86* | 26.88 ± 4.59 | 30.42 ± 1.44 |
| Asx | 53.63 ± 8.73 * | 115.39 ± 10.78*‡ | 51.81 ± 4.62 | 55.76 ± 4.95‡ |
| Met | 7.97 ± 0.35* | 12.33 ± 0.64* | 9.05 ± 1.44 | 10.79 ± 0.53 |
| Arg | 5.12 ± 0.22* | 15.19 ± 2.25* | 9.33 ± 3.09 | 16.75 ± 1.02 |
| Orn | 27.31 ± 1.50* | 73.22 ± 43.79* | 74.97 ± 11.22 | 64.05 ± 8.75 |
Data are means ± SEM. Ala, alanine; Arg, arginine; Asx, aspartic acid and asparagines; Glx, glutamic acid and glutamine; Met, methionine; Orn, ornithine; Phe, phenylalanine; Pro, proline; Ser, serine.
Gcgr+/+ vs. Gcgr−/−; *P < 0.01.
Gcgr+/+ STZ vs. Gcgr−/− STZ; †P < 0.001.
Gcgr−/− vs. Gcgr−/− STZ; ‡P < 0.05.