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. 2011 Jan 21;60(2):427–435. doi: 10.2337/db10-0409

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Foxc2 regulates mtTFA. A: 3T3-L1 cells were transiently transfected with a luciferase reporter plasmid harboring an mtTFA promoter and an increasing amount (0–400 ng) of FOXC2 expression vector. **P = 0.01. B: Real-time PCR analysis of mtTFA mRNA expression in white adipose tissue (WAT) and brown adipose tissue (BAT) derived from Foxc2 overexpressing mice (gray bars) and WT littermates (black bars). **P = 0.01; ***P = 0.001. C: Cotransfections in 3T3-L1 cells using mtTFA-promoter-luciferase reporter-construct and expression vectors for a selection of forkhead genes (Foxc2, Foxf2, Foxi1, and FoxO1). **P = 0.01; n = 3.