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. 2011 Jan 21;60(2):525–536. doi: 10.2337/db09-1305

FIG. 1.

FIG. 1.

A: Expression of HGF and c-Met mRNA in islets obtained from mice after 5 days of MLDS (40 mg/kg) administration (n = three mice/group). HGF and c-Met mRNA expression in islets treated in vitro (B) with 1 mmol/L STZ for 24 h or (C) with 50 units/mL of IL-1β, 1,000 units/mL TNF-α, 1,000 units/mL IFN-γ for 24 h, and (D) in βTC-3 insulinoma cells treated with the same concentration of cytokines for 16 h. Real-time PCR results are mean ± SEM of three experiments in triplicate. *P < 0.05 vs. untreated. HGF and c-Met protein expression (E) in islets obtained from mice after 5 days of MLDS administration and (F) in islets treated in vitro with 1,000 units/mL TNF-α, 1,000 units/mL IFN-γ, and 50 or 100 units/mL of IL-1β for 24 h. Western blot results are representative of three different experiments.