FIG. 1.

Diabetic kidney injury is enhanced in Smad7 KO mice. A: Blood glucose. Levels of blood glucose are significantly increased at week 2 after STZ injection and maintained at equal higher levels over the 24-week period in both Smad7 KO and WT mice. B: Urinary albumin exertion (UAE). Smad7 KO mice had more severe microalbuminuria than the WT mice. C: Histology (PAS-stained sections). Data are expressed as mean ± SE for group of eight mice. #P < 0.05 vs. WT DM group by 2-way ANOVA. Magnification ×400. (A high-quality color representation of this figure is available in the online issue.)