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. 2011 Jan 21;60(2):590–601. doi: 10.2337/db10-0403

FIG. 6.

FIG. 6.

Overexpression of renal Smad7 inhibits renal fibrosis in diabetic rats. AC: Collagen I expression. DG: Collagen IV expression. Results show that when compared with diabetic rats (DM) and diabetic rats with control vector treatment (VC), Smad7 gene transfer significantly inhibits renal collagen I and IV expression as demonstrated by immunohistochemistry (A, B, and DF) and real-time PCR at the mRNA levels (C and G). Data represent mean ± SE for groups of six animals. *P < 0.05, **P < 0.01, ***P < 0.001 vs. normal; #P < 0.05, ###P < 0.001 vs. DM and VC mice. Magnification ×200 (A and D). (A high-quality color representation of this figure is available in the online issue.)