TABLE 2.

Change in least squares means^* of common IMT over EDIC years 1, 6, and 12 by treatment group

	Change in least squares		Mean IMT difference (mm ± SE)
EDIC period	Intensive	Conventional	(Intensive − Conventional)	P
Years 1 to 6	0.016 ± 0.010	0.036 ± 0.010	−0.019 ± 0.005	<0.0001
Years 6 to 12	0.057 ± 0.005	0.051 ± 0.005	0.005 ± 0.006	0.379
Years 1 to 12	0.072 ± 0.011	0.086 ± 0.010	−0.014 ± 0.007	0.048

*From a single general linear mixed model with effects for treatment group, age, sex, study cohort, IMT at year 1, IMT reader, image device, EDIC year 6 or 12, and group by EDIC year interactions. Changes from years 1 to 6, 6 to 12, and 1 to 12 were estimated by contrasts among the model coefficients.