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. 2011 Jan 21;60(2):644–651. doi: 10.2337/db10-0346

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.

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FIG. 1. — A: Teglicar-dependent suppression of glucose and ketone bodies production by hepatocytes isolated from 16-h-fasted rats and incubated in presence of 10:1 lactate/pyruvate and 1 mmol/L oleate. B: Relationship between hepatocytes glucose production and the concentration of pyruvate/lactate in Krebs medium containing 1 mmol/L oleate in the presence or absence of 10 μmol/L teglicar. Each point represents the mean ± SE from eight different hepatocyte preparations in triplicate: ***P < 0.001; **P < 0.01 vs. control (CTRL) + oleate.