TABLE 3.
Associations of LN-transformed Gensini score with the three SNPs of 1,093 cases
| SNP (risk allele) | Quantitative trait association |
Case-control association* |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β | SE | r2 | P | P-adj† | Quartile risk AF (n) | P | OR (95% CI) | P-adj† | ||
| 1st (304) | 4th (265) | |||||||||
| rs2383208(G) | 0.053 | 0.047 | 0.001 | 0.134 | 0.567 | 0.428 | 0.381 | 0.111 | 1.21 (0.96–1.54) | 0.748 |
| rs10811661(T) | −0.066 | 0.044 | 0.002 | 0.263 | 0.488 | 0.378 | 0.406 | 0.345 | 0.89 (0.70–1.13) | 0.945 |
| rs10757283(C) | 0.267 | 0.045 | 0.032 | 2.48 × 10−9 | 0.002 | 0.401 | 0.583 | 9.50 × 10−10 | 2.09 (1.65–2.64) | 0.006 |
*The 1st and 4th quartiles of LN[Gensini score] distribution were used to carried out case-control association analysis. The 4th quartile was defined as the highest Gensini score quartile, which meant that patients in this quartile were in the worst condition of coronary atherosclerosis.
†Adjusted P values were obtained using multivariate logistic regression analysis with age, sex, hypertension, smoking history, BMI, glucose level, Tch, TG, HDL-c, and LDL-c level as covariates.