Table 3.
Prevalence of stage 3 or 4 chronic kidney disease calculated using the Modification of Diet in Renal Disease (MDRD) study equation and other cystatin C-based estimates, by body mass index
| Body mass index category (range, kg/m2) | ||||
|---|---|---|---|---|
| Normal weight (18.5 - 24.9) |
Overweight (25.0 − 29.9) |
Obesity (≥30.0) |
P- Trend |
|
| Stage 3 or 4 CKD prevalence, % (SE) | ||||
| eGFRcysC | 4.3 (0.5) | 7.1 (0.7) | 9.6 (1.1) | |
| eGFRMDRD | 4.2 (0.3) | 6.5 (0.5) | 7.4 (0.7) | |
| Difference | ||||
| eGFRcysC estimate minus eGFRMDRD estimate |
0.2 (0.3) | 0.6 (0.7) | 2.2 (0.8) | 0.03 |
| Stage 3 or 4 CKD prevalence, % (SE) | ||||
| Elevated cystatin C | 7.1 (0.7) | 11.7 (1.0) | 16.9 (1.8) | |
| eGFRMDRD | 4.2 (0.3) | 6.5 (0.5) | 7.4 (0.7) | |
| Difference | ||||
| Elevated cystatin C estimate minus eGFRMDRD estimate |
2.9 (0.5) | 5.2 (0.9) | 9.5 (1.4) | 0.0009 |
| Stage 3 or 4 CKD prevalence, % (SE) | ||||
| eGFRcreat, cysC, age, sex, race | 4.1 (0.4) | 6.1 (0.6) | 7.4 (0.8) | |
| eGFRMDRD | 4.2 (0.4) | 6.5 (0.6) | 7.4 (0.7) | |
| Difference | ||||
| eGFRcreat, cysC, age, sex, race estimate minus eGFRMDRD |
−0.1 (0.3) | −0.4 (0.4) | 0.0 (0.4) | 0.7 |
SE − Standard error
Prevalence of stage 3 or 4 CKD was defined by estimated glomerular filtration rate (eGFR):
eGFRcysC was derived from an equation including only cystatin C.
eGFRMDRD was derived from an equation including creatinine, age, sex, and race.
Elevated cystatin C was defined as cystatin C ≥ 1.12 mg/L (the 99th percentile for adults 20 to 39 years of age without hypertension, diabetes mellitus or CKD).
eGFRcreat, cysC, age, sex, race was derived from an equation including creatinine, cystatin C, age, sex, and race.